Comparison of different strategies for deformable dose accumulation in prostate cancer radiotherapy
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Online MR-guided radiotherapy (MRgRT) enables optimal plan adaptation with respect to the patient’s daily anatomy and thus allowing maximum target coverage and organ at risk (OAR) sparing. To date methods for deformable dose accumulation (DDA) are lacking, which would be a major prerequisite for the development of accurate dose-response models and precise clinical dose constraints. The aim of this study was to develop and implement different strategies of DDA and compare them to a fraction-based dose summation (DS).